Longevity Treatments
Evidence-based guides to longevity drugs and supplements. We break down how they work, what the evidence says, and what you should know before trying them.
This is your evidence-based guide to longevity interventions, from hormone therapies like TRT to longevity drugs like metformin and rapamycin, to NAD+ precursors like NMN and senolytic protocols.
Each guide includes: how the intervention works, the quality of evidence (we use a clear tier system), FDA approval status, potential benefits and risks, dosing information, and links to key studies. Looking for peptides? Check out our dedicated Peptides section.
FDA-Approved Options
These have been through rigorous clinical trials and are approved for human use. The strongest evidence and clearest safety profiles.
Research Compounds
Promising but not FDA-approved. These have varying levels of evidence, mostly from animal studies. Proceed with caution and realistic expectations.
Metformin
Longevity Drug
The diabetes drug everyone's taking for aging
Moderate EvidenceRapamycin
mTOR Inhibitor
The most promising longevity drug from mouse studies
Limited EvidenceNMN / NR
NAD+ Precursor
Boosting cellular energy with NAD+ precursors
EmergingSenolytics
Senescent Cell Clearance
Clearing zombie cells with dasatinib + quercetin
Curious about peptides?
We have a dedicated hub explaining what peptides are, which ones have evidence, the legal situation, and how to think about safety.